Cool Ultrasonic & Highly-Therapeutic Nebulizing Diffusers w/Free Yellow, Green and Red Mandarin Essential Oils…

All styles of our high-end cold-air Synergy Essentials® nebulizing diffusers are in stock, and our brand-new Ultrasonic diffusers have just arrived! Our professional cold-air diffusers are on sale for the next week at once-a-year discount… And with every diffuser comes a free 12ml bottle of each of organic Yellow, Green and Red Italian Mandarin essential oils.

Our best cold-air professional nebulizing diffusers are on sale, and every one comes with 12mls each of organic Yellow, Green and Red mandarin essential oils!

The cold air nebulizing diffuser makes a fine mist of only the essential oil, and we believe the most effective way of diffusing essential oils for therapeutic activity. We consider this the absolute best diffuser for immune system support and any therapeutic use where you’d want precise control over the amount of essential oil being diffused, whether it be just a little, or a whole lot.

Our customers ‘sound-off’ about their Synergy Essentials® diffusers:

  • “I LOVE this diffuser!!! Nothing else compares!! :)” ~ M.M
  • ” I love the Synergy Essentials nebulizer. It is my very favorite. It is very quiet, easy to clean, and the rates of diffusion can be varied by a turn of the knob.” ~ N.G.
  • ” I love this nebulizer – we have two. As good if not better than some of the more expensive ones and it’s actually pretty.” ~ S.S.

And now, finally, our cool-mist Ultrasonic diffusers have arrived!

These awesome units will fill your home with great scents. Their built-in automatic timers and measuring cups help make diffusing your oils as easy as can be.

Simply fill the internal cup with water, add a few drops of essential oil, twist the top back on and set the internal timer.

Remember, any diffuser ordered during this special will also come with 12ml each of organic Yellow, Red and Green Italian Mandarin essential oils!

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What is CBD and how do you use it? Here’s the Top Five questions YOU have been asking about our CBD Formulas…

Q: What exactly is CBD?

CBD is short for ‘cannabidiol’, the second most abundant cannabinoid found in common Cannabis sativa, and THE most abundant cannabinoid in nationwide-legal industrial hemp. Research is uncovering a number of potential health benefits of this cousin to THC which does not get one ‘high’ at all, but still closely interacts with cannabinoid receptors in our Central Nervous System and throughout our bodies.*

See all Ananda’s CBD 100, CBD Plus and CBD x3 Formulas here.

Here is a great introductory video on CBD (please note that this video discusses CBD from ‘high cbd strains’ of cannabis, not organic industrial hemp – though the CBD is precisely the same molecule from both plants!)

Q: Can the CBD formulas be applied to the skin?

Absolutely! CBD itself is lipophillic (meaning ‘fat friendly’) as are all the ingredients in every one of our formulas. Being lipophillic, they pass through the cell membranes of the skin, being absorbed primarily locally, with small amounts of the CBD and other ingredients passing into the bloodstream.

Topical CBD formulas have been used for have been used for the following conditions: Pain, inflammation, arthritis, dry/chapped skin, rheumatism, headaches & migraines, insect bites, sunburns, and psoriasis.*

As with any topical formula containing essential oils (as do our CBD ‘Plus’ and CBD ‘x3′), one should test for any skin sensitivity by applying a drop of your formula to the underside of one arm and checking for any redness over the next 24 hours, and discontinue topical use should such redness appear.

Q: How do I know which CBD formula to choose?

CBD 100 means ’100% CBD’. This is an excellent formula where other ingredients may not be helpful or necessary for your goals. You may also not be fond of the taste of other ingredients in the ‘Plus’ and ‘x3′ formulas. CBD 100 can be the most cost-effective means of supplementing with CBD, particularly if you find it supportive to your health goals.

CBD Plus includes a small amount of Hemp essential oil – the steam distillate of the same plant from which the CBD CO2 extract is made – which is rich in terpene molecules that may act synergistically with CBD. THIS IS THE FORMULA we recommend for the majority of those wanting to supplement with CBD, and the one many of us at Ananda use ourselves.

While both report begins with a look at THC, further in you’ll find in-depth information on the terpenoids in cannabis, as well as CBD itself:
http://steephilllab.com/resources/cannabinoid-and-terpenoid-reference-guide/
and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/

CBD x3 contains CBD, Hemp essential oil, and ‘super-critical’ extract of Frankincense ‘carteri’ resin. CBD and Frankincense have both been the subjects of anti-cancer research published in peer-reviewed scientific journals. It is purchased frequently by customers undergoing cancer therapies of some kind because of this research.

Each formula is based in MCT Coconut oil (know for its very ‘stable’ properties, this healthy oil along with the small amount of rosemary antioxidant also in every blend, helps preserve the more sensitive ingredients, like the CBD itself).

Q: I wanted to know if your cbd oils would reduce my anxiety or depression. do they interact with Ativan® or Paxil®?

CBD has been researched for its potentially positive affects on mood disorders. There are no known, as of yet, interactions with prescribed pharmaceutical drugs.

Q: Can you tell me what kind of recommendation you would have as far as which type of CBD to use and how to exactly use it for inflammation?

While we cannot ‘prescribe’ a formula for any particular medical condition, we ourselves use the CBD Plus formula for inflammation – both CBD and the terpenes found in hemp essential oil have been researched for their anti-inflammatory properties.

How each of us uses it depends on a number of things: how much pain are we experiencing, how sensitive are we to any herbs or other natural ‘medicines’, our height/weight/metabolism, etc.

We take CBD Plus internally, and generally start with a higher amount (anywhere from 15 to 45mg CBD per day) until we feel it supporting our condition, then slowly use less until we find that ‘sweet spot’ where we’re using just enough to meet our needs.

These amounts will vary from person to person, and because there are really no studies yet defining what a ‘daily serving’ may be, it is best to experiment for one’s self to find one’s own optimal intake.

Q: What dosage would one take for various conditions?

Just as described above for support for inflammation, the amount of CBD supplement one uses to support their health can vary greatly from person to person. We have scoured many resources to help give our customers more clear direction in this regard, yet we continue to find the same answer: there IS no definitive answer.

Those of us at The Ananda Apothecary who use our CBD formulas regularly supplement with approximately 10mg to 30mg per day (20 mg to 60 drops, as all formulas contain 1mg per 2 drops). These amounts are relative to our weight and general sensitivity to herbs and supplements (do we find a little of something often works for us, or do we only notice larger amounts?)…rather than being related to the ‘reason’ we are choosing to supplement with CBD.

Our Three High-Potency CBD Formulas - Click the Image To Learn More.

 

 

 

 

 

 

 

 

*These statements have not been evaluated by the Food and Drug Administration.These products are not intended to diagnose, treat, cure or prevent any disease.

 

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CBD Science Goes Deeper: Inflammation, Pain and Addiction Support

Important CBD Reasearch: Addiction, Chronic Pain, Inflammation and Cancer in Research

Inflammation Pathways

Inflammation has been connected to a number of health conditions.

In a quick recap, CBD is a CO2 oil extract from organically grown industrial hemp from Europe. CBD is the the primary ‘NON-Psychoactive’ cannabinoid in Cannabis sativa, and not only is it legal in all 50 states, but the price has come down so it can be afforded by all.

We offer several blends and sizes to suit your needs…have a look!

The body of data on CBD continues to grown, with scientific papers being produced on Chronic pain & inflammation, addiction and cancer. There appear to be multiple pathways which infammation production, as well as lessening the perception of pain. In terms of addiction, chronic pain is particularly of interest as often patients are treated with narcotic pain medications which can lead to addiction and abuse.*

CBD has been found to modulate and interact with many pathways including opiate pathways (pathways related to pain). CBD is able to bind to the opiate receptor (mu-opioid) in our brain that is a binding site for morphine and other pain relieving medications (5). As it binds to this receptor, it is able to modulate pain perception by activating the receptor and decreasing the sensation of pain (6). This is the same receptor that morphine acts upon and is able to yield the same pain relief without addiction.

CBD and Drug Addiction, in Addition to Pain Relievers

MU Receptors in the CNS

A brief picture of the MU/Opiod receptors in the Central Nervous System

Drug addiction is a common ailment, including alcoholism, cocaine addiction, tobacco and narcotic addition. Human studies have shown that it has been a potential positive indirect due to decrease stress vulnerability and brain toxicity (7). Studies have shown that CBD use has decreased morphine and cocaine use without or limited withdrawal symptoms of nausea, vomiting, hallucinations, and cold sweats (7).

CBD and Alcohol Withdrawal

CBD has also been used in alcohol withdrawal studies and has proven to alleviate withdrawal symptoms as well (8). Although the mechanism for alleviation of addiction is unknown, it is thought to be with regards to the reward behavior system in our brain due to the fact that CBD does work on dopaminergic pathways (9).

Research, CBD and Cancer

CBD has been shown to inhibit the progression of many types of cancer including glioblastoma (GBM), breast, lung, prostate and colon cancer (10). Although the mechanism for its mode of action is unknown, it has been proven that CBD does inhibit tumor cell growth, invasion, spread, and development even in late stages of cancer in human studies (11).

CBD & Anti-Inflammatory & Immune Response

Autoimmune disease and anti-inflammatory response go hand in had and often lead to pain. As mentioned above, pain management is one of the many therapeutic uses of CBD. However chronic pain does have other sources, especially with autoimmune diseases such as rheumatoid arthritis.

The big name players of these immune molecules are cytokines, Tumor Necrosis Factor Alpha (TNF-Alpha), and interleukin factors. Administration of CBD has shown to inhibit the production of cytokines, which are inflammatory markers in our body that then lead to the signals to increase inflammation (12). Thus inhibiting cytokines leads to decreased inflammation and thus alleviates pain perception. CBD is able to do this through binding of CB1 and CB2 receptors and inhibiting the immune response (12).

CBD also has been shown to inhibit many interleukin factors and tumor necrosis factors (TNF’s) that are also responsible for inflammation and immune response. This pathway is not as well known and there are multiple different pathways and mechanisms purposed, unfortunately due to the abundance of CB2 receptors on peripheral tissues (tissues that are not the brain and spinal cord) and immune cells, CBD can modulate and inhibit the release of interleukin factors and TNFs that promote immune response and inflammation (12).

This is may be especially important for those afflicted with autoimmune diseases. Autoimmune diseases are when the body’s immune response targets their own body’s produced cells that lead to inflammation and ultimately pain due to targeting their own body’s produced cells. Autoimmune diseases are typically treated with immune suppressing medications that often put these people at risk for other infections and illnesses due to being immune-compromised. CBD does not inhibit the body’s immune function from other pathogens and can be used as a therapeutic means of treatment for autoimmune diseases to alleviate flare-ups, inflammation, and pain.


Check Out Ananda Apothecary’s High-Strength CBD Formulas:

Our Three High-Potency CBD Formulas - Click the Image To Learn More.


In Conclusion

In conclusion, CBD has many therapeutic effects on all body systems, simply because cannabinoid receptors are located all throughout our body tissues, and since CBD works through the endo-cannabinoid system (our body’s own engogenous cannabinoid system), it is it appears to produce its effects by not only modulating our own endocannabinoids, but inhibiting inflammation responses through mechanisms not yet completely understood. Despite this grey areas of exact mechanisms, there are many proposed with significantly valuable evidence that is still being avidly researched today. Many of them deal with regulating and modulating our own endocannabinoids, anandamide and 2-AG, and CB1 and CB2 receptors.

*These statements have not been evaluated by the Food and Drug Administration.These products are not intended to diagnose, treat, cure or prevent any disease.

1. FM Leweke, D Piomelli, F Pahlisch, D Muhl, C W Gerth, C Hoyer, J Klosterkotter, M Hellmich, and D Koethe. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry. 2012 Mar; 2(3): e94

Link http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316151/

2. Stephen D Skaper and Vincenzo Di Marzo. Endocannabinoids in Nervous System Health and Disease: The Big Picture in a Nutshell. Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5; 367(1607): 3193–3200

Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481537/

3. Alline Cristina Campos, Fabricio Araujo Moreira, Felipe Villela Gomes, Elaine Aparecida Del Bel, and Francisco Silveira Guimaraes. Multiple Mechanisms Involved in the Large-Spectrum Therapeutic Potential of Cannabidiol in Pyschiatric Disorders. Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5; 367(1607): 3364–3378

Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481531/

4. Wolf SA, Bick-Sander A, Fabel K, Leal-Galicia P, Tauber S, Ramierz-Rodriguez G, Muller A, Melnick A, Waltinger TP, Ullrich O, Kempermann G. Cannabinoid Receptor CB1 Mediates Baseline and Activity-Induced Survival of New Neurons in Adult Hippocampal Neurogenesis. Cell Commun Signal. 2010 Jun 17;8:12

Link: http://www.ncbi.nlm.nih.gov/pubmed/20565726

 

5. Baron EP. Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It’s Been… Headache. 2015 May 25.

Link: http://www.ncbi.nlm.nih.gov/pubmed/26015168

 

1. NeelakantanH, Tallarida RJ, Reichenbach ZW, Tuma RF, Ward SJ, Walker EA. Distinct Interactions of Cannabidiol and Morphine in Three Nocicpetive Behavioral Models in Mice. Behav Pharmacol. 2015 Apr;26(3):304-14

Link: http://www.ncbi.nlm.nih.gov/pubmed/25485642

 

2. Melissa Prud’homme, Romulus Cata, and Didier Jutras-Aswad. Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence. Subst Abuse. 2015; 9: 33–38

Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444130/

 

3. Zuardi AW, Crippa JA, Hallak JE, Moreira FA, Guimaraes FS. Cannabidiol, aCannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res.2006;39(4):421–9

Link: http://www.ncbi.nlm.nih.gov/pubmed/16612464

 

4. Gardner EL. Endocannabinoid signaling system and brain reward: emphasis on dopamine. Pharmacol Biochem Behav. 2005;81(2):263–84

Link: http://www.ncbi.nlm.nih.gov/pubmed/15936806

 

5. McAllister SD, Soreceanu L, Desprez PY. The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids. J Neuroimmune Pharmacol. 2015 Jun;10(2):255-67

Link: http://link.springer.com/article/10.1007%2Fs11481-015-9608-y

 

6. Sean D McAllister, Ryuichi Murase, Rigel T Christian, Darryl Lau, Anne J Zielinski, Juanita Allison, Carolina Almanza, Arash Pakdel, Jasmine Lee, Chandani Limbad, Yong Liu, Robert J Debs, Dan H Moore, And Pierre-Yves Desprez. Pathways Mediating the Effects of Cannabidiol on the Reduction of Breast Cancer Cell Proliferation, Invasion, and Metastatis. Breast Cancer Res Treat. 2011 Aug; 129(1): 37–47.

Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410650/

 

12. Barbara L.F. Kaplan, Alison E.B. Springs, and Norbert E. Kaminski. The Profile of Immune Modulation by Cannabidiol (CBD) Involves Deregulation of Nuclear Factor of Activated T Cells (NFAT). Biochem Pharmacol. 2008 Sep 15; 76(6): 726–737..

Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748879/

 

 

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